Tamiflu: Prepared From Tamiflu Capsules

Extemporaneously Prepared

TamifluIf the commercially prepared oral suspension is not available, the manufacturer provides the following compounding information to prepare a 6 mg/mLsuspension in emergency situations.

1. Place the specified amount of water into a polyethyleneterephthalate (PET) or glass bottle.

2. Carefully separate the capsule body and cap and pour the contents of the required number of 75 mg capsules into the PET or glass bottle.

3. Gently swirl the suspension to ensure adequate wetting of the powder for at least 2 minutes.

4. Slowly add the specified amount of vehicle to the bottle.

5. Close the bottle using a child-resistant cap and shake well for 30 seconds to completely dissolve the active drug.

6. Label “Shake Well Before Use.”

Stable for 35 days refrigerated or 5 days at room temperature. Shake gently prior to use. Do not dispense with dosing device provided with commercially-available product.

Preparation of Oseltamivir 6 mg/mL Suspension
Body Weight Total Volume per Patient1 # of 75 mg Capsules2 Required Volume of Water Required Volume of Vehicle2,3 Treatment Dose (wt based)4 Prophylactic Dose (wt based)4
1Entire course of therapy.
2Based on total volume per patient.
3Acceptable vehicles are cherry syrup, Ora-Sweet® SF, or simple syrup.
4Using 6 mg/mL suspension.
≤15 kg 75 mL 6 5 mL 69 mL 5 mL (30 mg) twice daily for 5 days 5 mL (30 mg) once daily for 10 days
16-23 kg 100 mL 8 7 mL 91 mL 7.5 mL (45 mg) twice daily for 5 days 7.5 mL (45 mg) once daily for 10 days
24-40 kg 125 mL 10 8 mL 115 mL 10 mL (60 mg) twice daily for 5 days 10 mL (60 mg) once daily for 10 days
≥41 kg 150 mL 12 10 mL 137 mL 12.5 mL (75 mg) twice daily for 5 days 12.5 mL (75 mg) once daily for 10 days

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